USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: GDIB_HUMAN USC-OGP 2-DE database:  GDIB_HUMAN GDIB_HUMAN General information about the entry View entry in simple text format Entry name GDIB_HUMAN Primary accession number P50395 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Rab GDP dissociation inhibitor beta; Short=Rab GDI beta; AltName: Full=Guanosine diphosphate dissociation inhibitor 2; Short=GDI-2;. Gene name Name=GDI2 Synonyms=RABGDIB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0392: pI=5.92; Mw=46447 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0692: pI=5.90; Mw=45426 SPOT OGP-0697: pI=5.90; Mw=44865 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1162: pI=6.22; Mw=49435 SPOT OGP-1170: pI=6.23; Mw=47103 Cross-references UniProtKB/Swiss-Prot P50395; GDIB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GDIB_HUMAN Primary accession number P50395 Secondary accession number(s) O43928 Q5SX88 Q9UQM6 Sequence was last modified on  April 27, 2001 (version 2) Annotations were last modified on  March 15, 2017 (version 158) Name and origin of the protein Description RecName: Full=Rab GDP dissociation inhibitor beta; Short=Rab GDI beta; AltName: Full=Guanosine diphosphate dissociation inhibitor 2; Short=GDI-2; Gene name Name=GDI2 Synonyms=RABGDIB Encoded on Name=GDI2; Synonyms=RABGDIB Keywords Acetylation; Alternative splicing; Complete proteome; Cytoplasm; GTPase activation; Membrane; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D13988; BAA03095.1; -; mRNA EMBL Y13286; CAA73734.1; -; mRNA EMBL Y13287; CAA73735.1; -; Genomic_DNA EMBL Y13288; CAA73735.1; JOINED; Genomic_DNA EMBL Y13289; CAA73735.1; JOINED; Genomic_DNA EMBL Y13290; CAA73735.1; JOINED; Genomic_DNA EMBL Y13291; CAA73735.1; JOINED; Genomic_DNA EMBL Y13292; CAA73735.1; JOINED; Genomic_DNA EMBL Y13293; CAA73735.1; JOINED; Genomic_DNA EMBL Y13294; CAA73735.1; JOINED; Genomic_DNA EMBL Y13295; CAA73735.1; JOINED; Genomic_DNA EMBL Y13296; CAA73735.1; JOINED; Genomic_DNA EMBL Y13297; CAA73735.1; JOINED; Genomic_DNA EMBL BT006868; AAP35514.1; -; mRNA EMBL AK297554; BAG59947.1; -; mRNA EMBL AL596094; CAI13363.1; -; Genomic_DNA EMBL BC005145; AAH05145.1; -; mRNA EMBL AF144713; AAD34588.1; -; mRNA CCDS CCDS44352.1; -. [P50395-2]; . CCDS CCDS7071.1; -. [P50395-1]; . RefSeq NP_001108628.1; NM_001115156.1. [P50395-2]; . RefSeq NP_001485.2; NM_001494.3. [P50395-1]; . UniGene Hs.299055; -; . ProteinModelPortal P50395; -; . SMR P50395; -; . BioGrid 108933; 55; . DIP DIP-50593N; -; . IntAct P50395; 23; . MINT MINT-4999214; -; . STRING 9606.ENSP00000369538; -; . iPTMnet P50395; -; . PhosphoSitePlus P50395; -; . SwissPalm P50395; -; . BioMuta GDI2; -; . DMDM 13638228; -; . OGP P50395; -; . REPRODUCTION-2DPAGE IPI00031461; -; . REPRODUCTION-2DPAGE P50395; -; . EPD P50395; -; . PaxDb P50395; -; . PeptideAtlas P50395; -; . PRIDE P50395; -; . DNASU 2665; -; . Ensembl ENST00000380181; ENSP00000369528; ENSG00000057608. [P50395-2]; . Ensembl ENST00000380191; ENSP00000369538; ENSG00000057608. [P50395-1]; . GeneID 2665; -; . KEGG hsa:2665; -; . UCSC uc001iim.5; human. [P50395-1]; . CTD 2665; -; . DisGeNET 2665; -; . GeneCards GDI2; -; . HGNC HGNC:4227; GDI2; . HPA HPA049290; -; . HPA HPA057668; -; . MIM 600767; gene; . neXtProt NX_P50395; -; . OpenTargets ENSG00000057608; -; . PharmGKB PA28642; -; . eggNOG KOG1439; Eukaryota; . eggNOG COG5044; LUCA; . GeneTree ENSGT00530000063044; -; . HOGENOM HOG000163825; -; . HOVERGEN HBG000839; -; . InParanoid P50395; -; . KO K17255; -; . OMA PAMNEEY; -; . OrthoDB EOG091G06PV; -; . PhylomeDB P50395; -; . TreeFam TF300449; -; . Reactome R-HSA-194840; Rho GTPase cycle; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs; . ChiTaRS GDI2; human; . GeneWiki GDI2; -; . GenomeRNAi 2665; -; . PRO PR:P50395; -; . Proteomes UP000005640; Chromosome 10; . Bgee ENSG00000057608; -; . CleanEx HS_GDI2; -; . ExpressionAtlas P50395; baseline and differential; . Genevisible P50395; HS; . GO GO:0035578; C:azurophil granule lumen; TAS:Reactome; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0005794; C:Golgi apparatus; IEA:Ensembl; . GO GO:0016020; C:membrane; IEA:UniProtKB-SubCell; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0031982; C:vesicle; IDA:UniProtKB; . GO GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW; . GO GO:0016491; F:oxidoreductase activity; IEA:InterPro; . GO GO:0005093; F:Rab GDP-dissociation inhibitor activity; TAS:ProtInc; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0015031; P:protein transport; IEA:InterPro; . GO GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome; . GO GO:0007165; P:signal transduction; TAS:UniProtKB; . GO GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl; . Gene3D 3.50.50.60; -; 2; . InterPro IPR023753; FAD/NAD-binding_dom; . InterPro IPR018203; GDP_dissociation_inhibitor; . InterPro IPR000806; RabGDI; . PANTHER PTHR11787; PTHR11787; 1; . Pfam PF00996; GDI; 1; . PRINTS PR00892; RABGDI; . PRINTS PR00891; RABGDIREP; . SUPFAM SSF51905; SSF51905; 2; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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